Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 164
interventional 117
Observational 45
Registry 2

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 26
Drug|placebo 17
Device 16
Other 15
Procedure 13
Biological 8
Drug|Other 5
Dietary Supplement 4
Behavioral 2
Device|Drug 2
Dietary Supplement|placebo 2
Behavioral|Diagnostic Test 1
Biological|Other 1
Biological|placebo 1
Combination Product 1
Device|Other 1
Dietary Supplement|Other 1
Genetic 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 50
China 11
NA 11
Korea, Republic of 7
Canada 6
France 6
Australia 2
Germany 2
Italy 2
Turkey 2
Belgium|Czech Republic|Finland|France|Germany|Israel|Italy|Netherlands 1
Brazil 1
Israel 1
Malaysia|Singapore 1
Mexico 1
Poland 1
Russian Federation 1
Saudi Arabia 1
Spain 1
Sweden 1
Taiwan 1
United Kingdom 1
United States|Australia|Israel|New Zealand|Slovenia|Turkey 1
United States|Austria 1
United States|Austria|Belgium|Canada|Ireland|Netherlands|Qatar|Singapore|Sweden|United Kingdom 1
United States|Canada 1
United States|Finland|Israel|Italy|Japan|Korea, Republic of|Portugal|Spain|Sweden|United Kingdom 1
Vietnam 1

Sites per Study

Site_count Study_Count
1 73
2 13
3 2
4 2
5 1
6 3
8 1
9 2
11 2
13 3
14 1
16 3
17 2
19 1
20 2
21 1
22 1
33 1
35 1
39 1
40 1

Phase

Phase Study_Count
N/A 43
Phase 2 21
Phase 3 18
Phase 1 11
Phase 1/Phase 2 8
Phase 4 7
Phase 2/Phase 3 6
Early Phase 1 3

Number of Arms

Number_of_Arms Count_of_Studies
1 19
2 71
3 8
4 7
5 1
6 2
NA 9

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 30.00000 3.0000 9.00000 12.0 40.0000 100.0000 48.0000 2.0000
1st Qu. 33.00000 27.0000 9.50000 21.5 62.0000 107.5000 135.0000 47.0000
Median 36.00000 60.0000 12.00000 64.5 74.0000 265.0000 523.0000 88.0000
Mean 55.33333 335.6047 23.72727 163.5 112.6667 305.1667 613.9333 125.4286
3rd Qu. 68.00000 198.0000 35.00000 148.5 124.0000 463.0000 831.5000 104.0000
Max. 100.00000 4965.0000 72.00000 807.0 477.0000 617.0000 1824.0000 486.0000

Trial Group Type

group_type Group_Count
Experimental 111
Active Comparator 47
Placebo Comparator 38
Other 17
No Intervention 15
NA 9
Sham Comparator 2

Intervention Model

intervention_model Study_Count
Parallel Assignment 74
Single Group Assignment 23
Crossover Assignment 11
NA 6
Sequential Assignment 2
Factorial Assignment 1

Primary Purpose

primary_purpose Study_Count
Treatment 62
Prevention 38
Basic Science 5
Supportive Care 4
Other 3
Diagnostic 2
Educational/Counseling/Training 1
Screening 1
NA 1

Observational Studies

Studies by Country

Country Study_Count
United States 16
NA 10
China 5
Canada 3
France 2
Korea, Republic of 2
Switzerland 2
Denmark 1
Spain 1
United Kingdom 1
United States|Argentina 1
United States|Canada 1

Sites per Study

Site_count Study_Count
1 32
2 8
4 1
8 1
21 1
29 1
35 1

Enrollment Metrics

Measure Observational
Min 8.00
1st Qu 50.75
Median 185.50
Mean 528.60
3rd Qu 300.00
Max 5000.00

Observation Model

observational_model Study_Count
Cohort 23
NA 8
Case-Control 5
Case-Only 4
Other 4
Case Control 1

Time Perspective

time_perspective Study_Count
Prospective 30
Retrospective 6
NA 5
Cross-Sectional 3
Other 1

Registries

Studies by Country

Country Study_Count
Netherlands 1
United States 1

Sites per Study

Site_count Study_Count
1 1
4 1

Enrollment Metrics

Measure Registries
Min 165.0
1st Qu 292.5
Median 420.0
Mean 420.0
3rd Qu 547.5
Max 675.0

Registry Model

observational_model Study_Count
Cohort 2

Time Perspective

time_perspective Study_Count
Prospective 2

Follow-up

target_duration Study_Count
2 Years 1
22 Months 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT03242057 Comparison of Primary Extubation Failure Between NIPPV and NI-NAVA https://ClinicalTrials.gov/show/NCT03242057 Completed University of Florida 2019-09-05
NCT03385330 BPD Saturation TARgeting https://ClinicalTrials.gov/show/NCT03385330 Active, not recruiting Children’s Hospital of Philadelphia 2021-02-01
NCT03346343 Pulmonary Function Using Non-invasive Forced Oscillometry https://ClinicalTrials.gov/show/NCT03346343 Recruiting University of Alabama at Birmingham 2022-05-31
NCT03392467 PNEUMOSTEM for the Prevention and Treatment of Severe BPD in Premature Infants https://ClinicalTrials.gov/show/NCT03392467 Recruiting Medipost Co Ltd. 2021-06-30
NCT03388437 Non-invasive Neurally Adjusted Ventilatory Assist Versus Nasal Intermittent Positive Pressure Ventilation for Preterm Infants After Extubation https://ClinicalTrials.gov/show/NCT03388437 Recruiting King Fahad Armed Forces Hospital 2020-05-30
NCT03378063 Stem Cells for Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT03378063 Recruiting Daping Hospital and the Research Institute of Surgery of the Third Military Medical University 2022-12-30
NCT03372525 Invasive Ventilation Strategies for Neonates With Acute Respiratory Distress Syndrome Syndrome (ARDS) https://ClinicalTrials.gov/show/NCT03372525 Recruiting Daping Hospital and the Research Institute of Surgery of the Third Military Medical University 2020-12-31
NCT03938532 Feasibility and Impact of Volume Targeted Ventilation in the Delivery Room https://ClinicalTrials.gov/show/NCT03938532 Recruiting Baystate Medical Center 2020-12-31
NCT03253263 A Clinical Efficacy and Safety Study of SHP607 in Preventing Chronic Lung Disease in Extremely Premature Infants https://ClinicalTrials.gov/show/NCT03253263 Recruiting Shire 2025-02-28
NCT03231735 Mid and Standard Frequency Ventilation in Infants With Respiratory Distress Syndrome https://ClinicalTrials.gov/show/NCT03231735 Recruiting University of Alabama at Birmingham 2021-07-31
NCT03163108 Closed-loop Automatic Oxygen Control (CLAC-4) in Preterm Infants https://ClinicalTrials.gov/show/NCT03163108 Completed University Hospital Tuebingen 2017-12-18
NCT03142568 Safety of Sildenafil in Premature Infants https://ClinicalTrials.gov/show/NCT03142568 Recruiting University of North Carolina, Chapel Hill 2021-09-30
NCT03062709 A Study of Tobacco Smoke and Children With Respiratory Illnesses https://ClinicalTrials.gov/show/NCT03062709 Completed Maine Medical Center 2017-03-30
NCT02967549 Neurally Adjusted Ventilatory Assist vs Proportional Assist Ventilation https://ClinicalTrials.gov/show/NCT02967549 Completed King’s College London 2018-08-31
NCT02907593 Steroids and Surfactant in Extremely Low Gestation Age Infants Dose Escalation Trial https://ClinicalTrials.gov/show/NCT02907593 Completed Oregon Health and Science University 2018-04-30
NCT02819050 Effective Approaches & Strategies to Ease Off Nasal CPAP In Preterm Infants https://ClinicalTrials.gov/show/NCT02819050 Completed Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center 2016-01-31
NCT02788110 Work of Breathing During Non-invasive Ventilation in Premature Neonates https://ClinicalTrials.gov/show/NCT02788110 Completed Arkansas Children’s Hospital Research Institute 2018-06-30
NCT02784821 Antibiotic “Dysbiosis” in Preterm Infants https://ClinicalTrials.gov/show/NCT02784821 Completed University of Florida 2019-09-11
NCT02766673 Aerosolized Albuterol Use in Severe BPD https://ClinicalTrials.gov/show/NCT02766673 Completed Children’s Hospital of Philadelphia 2018-06-30
NCT02723513 Bronchopulmonary Dysplasia: From Neonatal Chronic Lung Disease to Early Onset Adult COPD https://ClinicalTrials.gov/show/NCT02723513 Recruiting Western University, Canada 2021-04-30
NCT02999373 Autologous Cord Blood Mononuclear Cells for Bronchopulmonary Dysplasia in Very Preterm Neonates https://ClinicalTrials.gov/show/NCT02999373 Completed Guangdong Women and Children Hospital 2020-01-01
NCT02527798 Safety of Furosemide in Premature Infants at Risk of Bronchopulmonary Dysplasia (BPD) https://ClinicalTrials.gov/show/NCT02527798 Active, not recruiting University of North Carolina, Chapel Hill 2020-05-31
NCT02475434 Use of Human Milk Cream to Decrease Length of Stay in Extremely Premature Infants https://ClinicalTrials.gov/show/NCT02475434 Active, not recruiting Baylor College of Medicine 2019-06-25
NCT02447250 Preterm Infant Inhaled Albuterol Dosing https://ClinicalTrials.gov/show/NCT02447250 Completed Oregon Health and Science University 2014-12-30
NCT02443961 Mesenchymal Stem Cell Therapy for Bronchopulmonary Dysplasia in Preterm Babies https://ClinicalTrials.gov/show/NCT02443961 Recruiting Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal 2020-04-30
NCT02371460 Maternal Omega-3 Supplementation to Reduce Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT02371460 Active, not recruiting CHU de Quebec-Universite Laval 2019-04-25
NCT02287116 Continuous Positive Airway Pressure Via Binasal Prong vs Nasal Mask: a Randomised Controlled Trial https://ClinicalTrials.gov/show/NCT02287116 Completed Zekai Tahir Burak Women’s Health Research and Education Hospital 2014-05-31
NCT02249143 Duration of Continuous Positive Airway Pressure and Pulmonary Function Testing in Preterm Infants https://ClinicalTrials.gov/show/NCT02249143 Completed Oregon Health and Science University 2016-05-31
NCT02210026 Seattle-PAP Bubble Nasal CPAP and Work of Breathing https://ClinicalTrials.gov/show/NCT02210026 Completed Seattle Children’s Hospital 2015-10-31
NCT02142621 Transpyloric Feeding in Severe Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT02142621 Completed Children’s Hospital of Philadelphia 2016-07-15
NCT02140580 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP https://ClinicalTrials.gov/show/NCT02140580 Active, not recruiting Menzies Institute for Medical Research 2020-05-31
NCT02128191 No Treatment Versus Oral Ibuprofen Treatment for Patent Ductus Arteriosus in Preterm Infants https://ClinicalTrials.gov/show/NCT02128191 Completed Samsung Medical Center 2019-08-31
NCT02102711 Oral Vitamin A Supplementation in Neonates With Birth Weight < 1500 g https://ClinicalTrials.gov/show/NCT02102711 Completed IRCCS Policlinico S. Matteo 2015-04-30
NCT01297205 Safety and Efficacy Evaluation of PNEUMOSTEM® Treatment in Premature Infants With Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT01297205 Completed Medipost Co Ltd. 2011-09-30
NCT01962818 High Frequency Oscillatory Ventilation Combined With Intermittent Sigh Breaths: Effects on Lung Volume Monitored by Electric Tomography Impedance. https://ClinicalTrials.gov/show/NCT01962818 Active, not recruiting Rigshospitalet, Denmark 2018-07-31
NCT01941745 Efficacy of Recombinant Human Clara Cell 10 Protein (rhCC10) Administered to Premature Neonates With Respiratory Distress Syndrome https://ClinicalTrials.gov/show/NCT01941745 Completed Tufts Medical Center 2017-08-25
NCT01897987 Follow-up Safety and Efficacy Evaluation on Subjects Who Completed PNEUMOSTEM® Phase-II Clinical Trial https://ClinicalTrials.gov/show/NCT01897987 Recruiting Medipost Co Ltd. 2020-04-30
NCT01828957 Efficacy and Safety Evaluation of Pneumostem® Versus a Control Group for Treatment of BPD in Premature Infants https://ClinicalTrials.gov/show/NCT01828957 Completed Medipost Co Ltd. 2015-05-31
NCT01739114 Assessment of Lung Aeration at Birth https://ClinicalTrials.gov/show/NCT01739114 Completed University of Alberta 2014-10-31
NCT01717625 The Efficacy and Safety of Montelukast Sodium in the Prevention of Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT01717625 Completed Ajou University School of Medicine 2013-10-31
NCT01702805 Transfusion of Prematures Trial https://ClinicalTrials.gov/show/NCT01702805 Active, not recruiting NICHD Neonatal Research Network 2020-01-31
NCT01600430 Vitamin D Supplementation for Extremely Preterm Infants https://ClinicalTrials.gov/show/NCT01600430 Completed University of Alabama at Birmingham 2014-12-31
NCT01503801 Inhaled Nitric Oxide to Prevent and Treat Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT01503801 Completed Fudan University 2012-09-30
NCT01473264 Safety, Pk and Anti-inflammatory Effects of CC10 Protein in Premature Infants With Respiratory Distress Syndrome (RDS) https://ClinicalTrials.gov/show/NCT01473264 Completed Clarassance, Inc. 2002-06-30
NCT01424553 Respiratory Outcome at Adolescence of Very Low Birthweight Infants https://ClinicalTrials.gov/show/NCT01424553 Completed Assistance Publique - Hôpitaux de Paris 2014-11-30
NCT01383850 NCPAP + Heliox as a Treatment for Infant Respiratory Distress Syndrome (RDS) https://ClinicalTrials.gov/show/NCT01383850 Completed Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico 2010-09-30
NCT03785899 Automatic Oxygen Control (SPOC) in Preterm Infants https://ClinicalTrials.gov/show/NCT03785899 Recruiting University Hospital Tuebingen 2019-08-01
NCT01353313 Hydrocortisone for BPD https://ClinicalTrials.gov/show/NCT01353313 Active, not recruiting NICHD Neonatal Research Network 2020-08-31
NCT04311476 Autologous Cord Blood Cells for Prevention of BPD in Preterm https://ClinicalTrials.gov/show/NCT04311476 Completed Guangdong Women and Children Hospital 2020-01-01
NCT04239690 Preservation of Blood in Extremely Preterm Infants https://ClinicalTrials.gov/show/NCT04239690 Recruiting Lund University 2022-10-31
NCT04209088 Interest of Pulmonary Ultrasound to Predict Evolution Towards Bronchopulmonary Dysplasia in Premature Infants at Gestational Age Less Than or Equal to 34 Weeks of Gestation https://ClinicalTrials.gov/show/NCT04209088 Recruiting University Hospital, Limoges 2022-03-06
NCT04077333 MISA to NRDS：a Multicenter Study in China https://ClinicalTrials.gov/show/NCT04077333 Completed Peking University Third Hospital 2018-11-30
NCT04068558 sNIPPV Versus NIV-NAVA in Extremely Premature Infants https://ClinicalTrials.gov/show/NCT04068558 Recruiting Centre Hospitalier Intercommunal Creteil 2020-09-30
NCT04062136 Umbilical Cord Mesenchymal Stem Cells Transplantation in the Treatment of Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT04062136 Recruiting Vinmec Research Institute of Stem Cell and Gene Technology 2020-11-30
NCT04003857 Follow-up Study of Safety and Efficacy in Subjects Who Completed PNEUMOSTEM® Phase II (MP-CR-012) Clinical Trial https://ClinicalTrials.gov/show/NCT04003857 Recruiting Medipost Co Ltd. 2027-06-30
NCT03961139 Continuous Versus Intermittent Bolus Feeding in Very Preterm Infants - Effect on Respiratory Morbidity https://ClinicalTrials.gov/show/NCT03961139 Recruiting National University Hospital, Singapore 2022-06-30
NCT03946891 Nebulized Furosemide in Premature Infants With Bronchopulmonary Dysplasia - A Cross Over Pilot Study of Its Efficacy and Safety https://ClinicalTrials.gov/show/NCT03946891 Recruiting NYU Langone Health 2023-06-30
NCT03895242 Prone and Supine Positions in Preterm Infants Receiving Mechanical Ventilation https://ClinicalTrials.gov/show/NCT03895242 Completed Akdeniz University 2016-06-30
NCT03876704 Effects of Fat-soluble Vitamins Supplementation on Common Complications and Neural Development in Very Low Birth Weight Infants https://ClinicalTrials.gov/show/NCT03876704 Recruiting First Affiliated Hospital Xi’an Jiaotong University 2019-09-30
NCT03873506 Follow-Up Study of Mesenchymal Stem Cells for Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT03873506 Recruiting Children’s Hospital of Chongqing Medical University 2020-07-01
NCT03775785 Targeted vs Standard Fortification of Breast Milk https://ClinicalTrials.gov/show/NCT03775785 Recruiting Princess Anna Mazowiecka Hospital, Warsaw, Poland 2021-12-31
NCT03774537 Human Mesenchymal Stem Cells For Infants At High Risk For Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT03774537 Recruiting Children’s Hospital of Chongqing Medical University 2020-12-01
NCT03701074 Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus https://ClinicalTrials.gov/show/NCT03701074 Recruiting University of South Alabama 2020-08-31
NCT03649932 Enteral L Citrulline Supplementation in Preterm Infants - Safety, Efficacy and Dosing https://ClinicalTrials.gov/show/NCT03649932 Recruiting The University of Texas Medical Branch, Galveston 2019-09-10
NCT03645525 Intratracheal Umbilical Cord-derived Mesenchymal Stem Cell for the Treatment of Bronchopulmonary Dysplasia (BPD) https://ClinicalTrials.gov/show/NCT03645525 Recruiting Children’s Hospital of Fudan University 2020-10-30
NCT03631420 Mesenchymal Stem Cells for The Treatment of Bronchopulmonary Dysplasia in Infants https://ClinicalTrials.gov/show/NCT03631420 Recruiting Meridigen Biotech Co., Ltd. 2020-10-31
NCT03613987 Randomized Control Trial: Synchronized Non-invasive Positive Pressure Ventilation Versus Non Synchronized Non Invasive Positive Pressure Ventilation in Extremely Low Birth Weight Infants https://ClinicalTrials.gov/show/NCT03613987 Recruiting New York Medical College 2019-04-26
NCT03576885 Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT03576885 Recruiting AdventHealth 2021-08-31
NCT03558334 Human Mesenchymal Stem Cells For Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT03558334 Recruiting Children’s Hospital of Chongqing Medical University 2021-12-31
NCT03546543 The Effects of Position on the Oxygenation Instability of Premature Infants as Documented by SpO2 Histograms https://ClinicalTrials.gov/show/NCT03546543 Completed Rambam Health Care Campus 2019-12-31
NCT03542812 L-citrulline and Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT03542812 Recruiting University of Utah 2021-06-30
NCT03540680 p16Ink4a in Bronchopulmonary Dysplasia in Children https://ClinicalTrials.gov/show/NCT03540680 Recruiting Centre Hospitalier Intercommunal Creteil 2019-12-01
NCT03538977 Hydrotherapy in Premature Infants With Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT03538977 Recruiting Universidade Estadual de Londrina 2019-05-31
NCT03532555 Enteral Zinc to Improve Growth in Infants at Risk for Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT03532555 Recruiting University of Utah 2021-06-30
NCT03521063 Efficacy of Adding Budesonide to Poractant Alfa to Prevent Bronchopulmonary Dysplasia. https://ClinicalTrials.gov/show/NCT03521063 Recruiting Hospital Central “Dr. Ignacio Morones Prieto” 2019-10-30
NCT03512158 Non-invasive Respiratory Support in Preterm Infants https://ClinicalTrials.gov/show/NCT03512158 Recruiting McMaster Children’s Hospital 2021-12-31
NCT03503994 Inhaled Corticosteroids for Treatment of Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT03503994 Completed Mount Sinai Hospital, Canada 2006-11-15
NCT03485703 Azithromycin in the Prevention of Lung Injury in Premature Newborn https://ClinicalTrials.gov/show/NCT03485703 Completed Hospital de Clinicas de Porto Alegre 2016-04-13
NCT03467828 Investigation of Polymorphisms in Bronchopulmonary Dysplasia In Turkish Population https://ClinicalTrials.gov/show/NCT03467828 Completed Kanuni Sultan Suleyman Training and Research Hospital 2018-04-05
NCT03455686 Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease https://ClinicalTrials.gov/show/NCT03455686 Recruiting McMaster University 2023-03-31
NCT01223274 Delivery Room CPAP in Extremely Low Birth Weight Infants https://ClinicalTrials.gov/show/NCT01223274 Completed NICHD Neonatal Research Network 2003-01-31
NCT01203488 Vitamin A Supplementation for Extremely-Low-Birth-Weight Infants https://ClinicalTrials.gov/show/NCT01203488 Completed NICHD Neonatal Research Network 1997-07-31
NCT01203358 Exosurf Neonatal and Survanta for Treatment of Respiratory Distress Syndrome https://ClinicalTrials.gov/show/NCT01203358 Completed NICHD Neonatal Research Network 1992-01-31
NCT01124331 Appropriate Oxygen Levels for Extremely Preterm Infants: a Prospective Meta-analysis https://ClinicalTrials.gov/show/NCT01124331 Completed University of Sydney 2014-08-31
NCT01039285 Exogenous Surfactant in Very Preterm Neonates in Prevention of Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT01039285 Active, not recruiting Maternite Regionale Universitaire 2012-12-31
NCT01035190 Efficacy and Safety of Inhaled Budesonide in Very Preterm Infants at Risk for Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT01035190 Completed University Children’s Hospital Tuebingen 2013-10-31
NCT01030575 Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2) https://ClinicalTrials.gov/show/NCT01030575 Completed NICHD Neonatal Research Network 2011-05-31
NCT01006629 Palivizumab for Prevention of Severe Respiratory Syncytial Virus Infection in Russian Children https://ClinicalTrials.gov/show/NCT01006629 Completed Abbott 2010-04-30
NCT00955487 Examining the Use of Non-Invasive Inhaled Nitric Oxide to Reduce Chronic Lung Disease in Premature Newborns https://ClinicalTrials.gov/show/NCT00955487 Completed University of Colorado, Denver 2014-07-31
NCT00931632 Inhaled Nitric Oxide (INO) for the Prevention of Bronchopulmonary Dysplasia (BPD) in Preterm Infants https://ClinicalTrials.gov/show/NCT00931632 Completed Mallinckrodt 2013-05-31
NCT00926276 The Role of Anti-Reflux Surgery for Gastroesophageal Reflux Disease in Premature Infants With Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT00926276 Completed The University of Texas Health Science Center, Houston 2013-05-31
NCT00840983 Effects of Delayed Cord Clamping in Very Low Birth Weight Infants https://ClinicalTrials.gov/show/NCT00840983 Completed University of Rhode Island 2005-11-30
NCT03857841 A Safety Study of IV Stem Cell-derived Extracellular Vesicles (UNEX-42) in Preterm Neonates at High Risk for BPD https://ClinicalTrials.gov/show/NCT03857841 Recruiting United Therapeutics 2021-12-31
NCT03086473 Early Caffeine in Preterm Neonates https://ClinicalTrials.gov/show/NCT03086473 Recruiting Children’s Hospital Los Angeles 2021-01-31
NCT02381366 Safety and Efficacy of PNEUMOSTEM® in Premature Infants at High Risk for Bronchopulmonary Dysplasia (BPD) - a US Study https://ClinicalTrials.gov/show/NCT02381366 Completed Medipost America Inc. 2016-09-30
NCT01440647 Study of Nasal Ventilation In Preterm Infants To Decrease Time on The Respirator https://ClinicalTrials.gov/show/NCT01440647 Completed Women and Infants Hospital of Rhode Island 2009-07-31
NCT00623740 PREMILOC Trial to Prevent Bronchopulmonary Dysplasia in Very Preterm Neonates https://ClinicalTrials.gov/show/NCT00623740 Completed Assistance Publique - Hôpitaux de Paris 2016-01-31
NCT00569530 Trial of Late Surfactant to Prevent BPD: A Pilot Study in Ventilated Preterm Neonates Receiving Inhaled Nitric Oxide https://ClinicalTrials.gov/show/NCT00569530 Completed University of California, San Francisco 2012-12-31
NCT00515281 Inhaled Nitric Oxide and Neuroprotection in Premature Infants https://ClinicalTrials.gov/show/NCT00515281 Active, not recruiting University of Chicago 2020-03-31
NCT00492102 Montelukast in Very Low Birthweight Infants https://ClinicalTrials.gov/show/NCT00492102 Completed Children’s Hospital Medical Center, Cincinnati 2011-06-30
NCT00433212 Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV) https://ClinicalTrials.gov/show/NCT00433212 Completed McMaster University 2011-08-31
NCT00349726 Single-Dose Intravenous Inositol Pharmacokinetics in Preterm Infants https://ClinicalTrials.gov/show/NCT00349726 Completed NICHD Neonatal Research Network 2007-12-31
NCT00319956 Trial II of Lung Protection With Azithromycin in the Preterm Infant https://ClinicalTrials.gov/show/NCT00319956 Completed University of Kentucky 2012-06-30
NCT00314431 Post-hospitalization Nursing Effectiveness (PHONE) Study https://ClinicalTrials.gov/show/NCT00314431 Completed Wake Forest University Health Sciences NA
NCT00233324 Surfactant Positive Airway Pressure and Pulse Oximetry Trial https://ClinicalTrials.gov/show/NCT00233324 Completed NICHD Neonatal Research Network 2009-02-28
NCT00208039 Pilot Trial of Surfactant Booster Prophylaxis For Ventilated Preterm Neonates https://ClinicalTrials.gov/show/NCT00208039 Completed Children’s Hospital of Philadelphia NA
NCT00167544 Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants https://ClinicalTrials.gov/show/NCT00167544 Completed Nationwide Children’s Hospital 2009-01-31
NCT00067613 Benchmarking Initiative to Reduce Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT00067613 Completed NICHD Neonatal Research Network 2004-05-31
NCT00188968 Randomized Trial of Nasal Continuous Positive Airway Pressure or Synchronized Nasal Ventilation in Premature Infants. https://ClinicalTrials.gov/show/NCT00188968 Completed University of Manitoba NA
NCT00011362 Dexamethasone Therapy in VLBW Infants at Risk of CLD https://ClinicalTrials.gov/show/NCT00011362 Completed NICHD Neonatal Research Network 1994-01-31
NCT00006401 Inhaled Nitric Oxide for Preventing Chronic Lung Disease in Premature Infants https://ClinicalTrials.gov/show/NCT00006401 Completed University of Colorado, Denver 2005-09-30
NCT00004805 Study of the Effect of Four Methods of Cardiopulmonary Resuscitation Instruction on Psychosocial Response of Parents With Infants at Risk of Sudden Death https://ClinicalTrials.gov/show/NCT00004805 Completed Office of Rare Diseases (ORD) NA
NCT00004785 Phase III Randomized, Double-Blind Study of Dexamethasone Vs Dexamethasone/Methylprednisolone Vs Placebo for Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT00004785 Completed Office of Rare Diseases (ORD) NA
NCT00004669 Phase II Pilot Study of Early Cortisol Replacement to Prevent Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT00004669 Completed Office of Rare Diseases (ORD) NA
NCT00000576 Inhaled Beclomethasone to Prevent Chronic Lung Disease https://ClinicalTrials.gov/show/NCT00000576 Completed National Heart, Lung, and Blood Institute (NHLBI) NA
NCT00000567 High Frequency Ventilation in Premature Infants (HIFI) https://ClinicalTrials.gov/show/NCT00000567 Completed National Heart, Lung, and Blood Institute (NHLBI) NA
NCT00000548 Inhaled NO in Prevention of Chronic Lung Disease https://ClinicalTrials.gov/show/NCT00000548 Completed University of California, San Francisco NA

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT04278404 Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) https://ClinicalTrials.gov/show/NCT04278404 Recruiting Duke University 2024-04-24
NCT03411018 Respiratory Management of Preterm Infants and Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT03411018 Completed Hospital General Universitario Gregorio Marañon 2017-12-31
NCT03373539 Neurotrophin Expression in Infants as a Predictor of Respiratory and Neurodevelopmental Outcomes https://ClinicalTrials.gov/show/NCT03373539 Completed The Cleveland Clinic 2019-08-31
NCT03229967 Gastrointestinal Microbiome Influence on the Development of Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT03229967 Enrolling by invitation University of Tennessee 2020-12-30
NCT03014453 GER Poses a Potential Risk for Late Complications of BPD https://ClinicalTrials.gov/show/NCT03014453 Completed Shengjing Hospital 2018-06-30
NCT02935140 Safe Use of Speaking Valve in Children During Sleep Using Trans-tracheal Pressure Measurement https://ClinicalTrials.gov/show/NCT02935140 Completed St Mary’s Hospital for Children 2016-06-30
NCT02921308 Pulmonary MRI of Ex-preterm Children With and Without BPD To Understand Risk of Emphysematous Changes https://ClinicalTrials.gov/show/NCT02921308 Recruiting Children’s Hospital of Eastern Ontario 2019-10-31
NCT02820818 Pulmonary Outcomes of Bronchopulmonary Dysplasia in Young Adulthood https://ClinicalTrials.gov/show/NCT02820818 Active, not recruiting St. Justine’s Hospital 2017-04-30
NCT02083562 Biomarkers and Volumetric Capnography in BPD https://ClinicalTrials.gov/show/NCT02083562 Completed University Hospital, Basel, Switzerland 2018-06-30
NCT01996670 Early NCPAP Before Surfactant Treatment in Very Preterm Infants With RDS https://ClinicalTrials.gov/show/NCT01996670 Completed Xiangya Hospital of Central South University 2012-12-31
NCT01748565 Gastrin-Releasing Peptide and Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT01748565 Completed Duke University 2016-08-31
NCT01722760 Tidal Neonatal NO, Vitamins A and D, and Infant Lung Disease - The AD-ON Study https://ClinicalTrials.gov/show/NCT01722760 Completed Hillerod Hospital, Denmark 2015-11-30
NCT01648855 Consequences of Antiangiogenic Factors Involved in Preeclampsia on Intra-uterine Growth Restricted Preterm Newborn https://ClinicalTrials.gov/show/NCT01648855 Completed Assistance Publique - Hôpitaux de Paris 2015-12-31
NCT01644981 Prospective Study on Plasma Pro-endothelin-1 in Predicting Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT01644981 Completed University of Zurich 2013-09-30
NCT01632475 Follow-Up Study of Safety and Efficacy of Pneumostem® in Premature Infants With Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT01632475 Active, not recruiting Samsung Medical Center 2025-09-30
NCT01607216 Functional and Lymphocytic Markers of Respiratory Morbidity in Hyperoxic Preemies https://ClinicalTrials.gov/show/NCT01607216 Completed University of Rochester 2015-07-31
NCT01516398 Predictors of Pulmonary Hypertension Risk in Premature Infants With Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT01516398 Active, not recruiting Stanford University 2022-01-31
NCT01460576 Improving Prematurity-Related Respiratory Outcomes at Vanderbilt https://ClinicalTrials.gov/show/NCT01460576 Completed Vanderbilt University Medical Center 2016-12-31
NCT01439295 Ascorbyl Peroxide Association With Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT01439295 Completed St. Justine’s Hospital 2015-11-30
NCT02023788 Long-term Safety and Efficacy Follow-up Study of PNEUMOSTEM® in Patients Who Completed PNEUMOSTEM® Phase-I Study https://ClinicalTrials.gov/show/NCT02023788 Completed Medipost Co Ltd. 2016-10-31
NCT04348799 Thrombocytopoiesis and Platelet Homeostasis in Infants With Bronchoplumonary Dysplasia https://ClinicalTrials.gov/show/NCT04348799 Completed Guangdong Women and Children Hospital 2020-01-01
NCT04237844 Clinic Features and Outcome of BPD (SGBPD) https://ClinicalTrials.gov/show/NCT04237844 Enrolling by invitation Children’s Hospital of Chongqing Medical University 2020-12-30
NCT04195672 NIPE as an Indicator of Pain in Sedated/Ventilated Patient Under 3 Years-old Hospitalized in Intensive Care Unit https://ClinicalTrials.gov/show/NCT04195672 Completed University Hospital, Lille 2019-04-25
NCT04184648 Comparison of Classification Standards of BPD in Premature Infants https://ClinicalTrials.gov/show/NCT04184648 Active, not recruiting Children’s Hospital of Chongqing Medical University 2020-08-20
NCT04163822 Analysis of BPD in Premature Infants With Typical Imaging Changes https://ClinicalTrials.gov/show/NCT04163822 Enrolling by invitation Children’s Hospital of Chongqing Medical University 2020-06-30
NCT04107701 Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD https://ClinicalTrials.gov/show/NCT04107701 Recruiting Boston Children’s Hospital 2024-07-31
NCT03797183 Genesis Electrical Impedance Tomography (EIT): A Preliminary Study https://ClinicalTrials.gov/show/NCT03797183 Recruiting University of Colorado, Denver 2022-02-28
NCT03717584 A Cohort Study of the Intestinal Microbiota of Premature Infants https://ClinicalTrials.gov/show/NCT03717584 Recruiting University of California, Davis 2023-12-31
NCT03657693 MRI in BPD Subjects https://ClinicalTrials.gov/show/NCT03657693 Recruiting Children’s Hospital Medical Center, Cincinnati 2021-06-01
NCT03475264 MRI of Lung Structure and Function in Preterm Children https://ClinicalTrials.gov/show/NCT03475264 Recruiting The Hospital for Sick Children 2020-12-31
NCT01223287 Physiologic Definition of Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT01223287 Completed NICHD Neonatal Research Network 2008-05-31
NCT03808402 The Effect of Surfactant Dose on Outcomes in Preterm Infants With RDS https://ClinicalTrials.gov/show/NCT03808402 Recruiting Chiesi UK 2020-10-26
NCT01780155 Genes Associated With Bronchopulmonary Dysplasia and Retinopathy of Prematurity https://ClinicalTrials.gov/show/NCT01780155 Recruiting National Institutes of Health Clinical Center (CC) 2022-09-26
NCT00757146 Neonatal Intensive Care (NICU) Course and Hospital Outcome of Infants With BPD Treated Using Inhaled Nitric Oxide https://ClinicalTrials.gov/show/NCT00757146 Completed University of Utah 2010-02-28
NCT00428038 Assessment of the Pulmonary Diffusion Capacity in Healthy Infants and Infants With Chronic Lung Disease https://ClinicalTrials.gov/show/NCT00428038 Completed Indiana University NA
NCT00422305 Assessment of Lung Structure and Function of Infants Born Prematurely https://ClinicalTrials.gov/show/NCT00422305 Completed Indiana University 2019-01-31
NCT00419588 Growth of Airways and Lung Tissues in Premature and Healthy Infants https://ClinicalTrials.gov/show/NCT00419588 Completed Indiana University 2019-01-31
NCT00234247 Prolonged Outcomes After Nitric Oxide (PrONOx) https://ClinicalTrials.gov/show/NCT00234247 Completed University of Pittsburgh 2008-11-30
NCT00006058 Study of the Pathobiology of Bronchopulmonary Dysplasia in Newborns https://ClinicalTrials.gov/show/NCT00006058 Completed National Center for Research Resources (NCRR) NA
NCT00005683 Clinical Interventions in Respiratory Distress Syndrome and Neonatal Lung Injury - SCOR in Lung Biology and Diseases in Infants and Children https://ClinicalTrials.gov/show/NCT00005683 Completed University of Rochester NA
NCT00005376 Premature Birth and Its Sequelae in Women https://ClinicalTrials.gov/show/NCT00005376 Completed National Heart, Lung, and Blood Institute (NHLBI) NA
NCT00005294 Developmental Sequelae of Severe Chronic Lung Disorders https://ClinicalTrials.gov/show/NCT00005294 Completed National Heart, Lung, and Blood Institute (NHLBI) NA
NCT00005293 Antecedents of Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT00005293 Completed National Heart, Lung, and Blood Institute (NHLBI) NA
NCT00005289 Risk Factors in Bronchopulmonary Dysplasia (Newborn Lung Project) https://ClinicalTrials.gov/show/NCT00005289 Completed University of Wisconsin, Madison 2008-07-31
NCT00005287 Late Sequelae of Bronchopulmonary Dysplasia https://ClinicalTrials.gov/show/NCT00005287 Completed Stanford University NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT02729844 Neolifes Heart - Pulmonary Hypertension in Preterm Children https://ClinicalTrials.gov/show/NCT02729844 Recruiting University Medical Center Groningen 2020-04-30
NCT03782610 Early Prediction of Spontaneous Patent Ductus Arteriosus (PDA) Closure and PDA-Associated Outcomes https://ClinicalTrials.gov/show/NCT03782610 Recruiting Nationwide Children’s Hospital 2024-12-31